You will see that everyone respects them, so it will be widespread for you to drive on a motorway with many lanes and all the cars at the same speed in the different paths.
The speed limits vary according to the roads and highways, so look carefully in each case which is the established limit. A limit of 60 miles per hour is customary.
You will be surprised to find trucks on the highways circulating in the lane on the left at a contained speed, and without moving in any case to the roads on the right. You should overtake them on the right.
During your trip on the highways in the United States, you will find numerous areas with all kinds of services: gas stations, several motels of different chains, several fast food restaurants.
In short, you will not have any problem when you need to refuel the car, eat, or choose where to sleep.
However, it is not the same when you drive on the roads of the interior of the west coast, visiting national parks of Utah or Arizona. The service areas are between 50 and 70 kilometers away, so you should plan your needs well.
The signaling highways and road are usually excellent, making it easy to locate places to visit. However, in the vicinity of large cities, you have to be very attentive to signaling as there is usually a very complex conglomerate of motorways.
At the time of accessing a large city in your rental car, you should have a lot of attention, but it is not difficult to reach your destination in cities such as San Francisco, Los Angeles, and Washington.
A separate case is that of Los Angeles, an incredibly large city where it is not so easy to orient and move around it.
Consequently, the use of a GPS device can be highly recommended. If you do not have it, you can rent it next to the car.
As a complement, it will be useful to know how and where to park the car in the cities of the United States, and also, these tips for renting a car in the United States.